Article
T cell selection and differential activation on structurally related HLA-DR4 ligands.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2001
Gebe J A, Novak E J, Kwok W W, Farr A G, Nepom G T, Buckner J H
Abstract excerpt
Plasticity of TCR interactions during CD4(+) T cell activation by an MHC-peptide complex accommodates variation in the peptide or MHC contact sites in which recognition of an altered ligand by the T cell can modify the T cell response. To explore the contribution of this form of TCR cross-recognition in the context of T cell selection on disease-associated HLA molecules, we have analyzed the relationship between...
Topics
- Animals
- Antigen Presentation
- Arthritis, Rheumatoid
- Autoimmune Diseases
- B-Lymphocytes
- Biopolymers
- CD4-Positive T-Lymphocytes
- Cell Differentiation
- Cell Line
- Cells, Cultured
- Clonal Deletion
- Epitopes
- Genotype
- HLA-DR Antigens