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Article

Antigen-specific T cells with monogamous or promiscuous restriction patterns are sensitive to different HLA-DR beta chain substitutions.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1991

Karr R W, Panina-Bordignon P, Yu W Y, Lanzavecchia A

Abstract excerpt

The contributions of the amino acids at 13 polymorphic positions in the HLA-DR7 beta 1 chain to T cell recognition of two antigenic peptides of tetanus toxin (p2 and p30) were assessed using transfectants expressing mutant DR7 beta 1 chains as APC for six toxin-specific T cell clones with two different restriction patterns: monogamous (restricted by DR7 only) or promiscuous (restricted by DR7; DR1; DR2, Dw21; and...

Topics

Amino Acid Sequence
Clone Cells
HLA-DR Antigens
Humans
Molecular Sequence Data
Mutation
Structure-Activity Relationship
T-Lymphocytes
Tetanus Toxin
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 2040799

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2040799-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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