Article
Changing the peptide specificity of a human T-cell receptor by directed evolution.
Nature communications - 7 Nov 2014
Smith Sheena N, Wang Yuhang, Baylon Javier L, Singh Nishant K, Baker Brian M, Tajkhorshid Emad, Kranz David M
Abstract excerpt
Binding of a T-cell receptor (TCR) to a peptide/major histocompatibility complex is the key interaction involved in antigen specificity of T cells. The recognition involves up to six complementarity determining regions (CDR) of the TCR. Efforts to examine the structural basis of these interactions and to exploit them in adoptive T-cell therapies has required the isolation of specific T-cell clones and their...
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