Induction of growth factor-independence and GM-CSF secretion by the v-src oncogene in murine myeloid cells does not require membrane association of pp60v-src.

Abstract excerpt

Introduction of v-src or c-src527F, a transforming mutant of the c-src proto-oncogene, into the growth factor-dependent cell line FDCP-1 resulted in growth factor independence. Temperature-shift studies with cells carrying the tsLA29 mutant of v-src demonstrated that growth factor independence wa...

Topics

• Animals
• Cell Division
• Cell Membrane
• Cell Transformation, Viral
• DNA, Recombinant
• Gene Expression Regulation
• Genes, Reporter
• Genes, src
• Granulocyte-Macrophage Colony-Stimulating Factor
• Hematopoietic Stem Cells
• Interleukin-3
• Mice
• Mitomycin
• Mutation
• Oncogene Protein pp60(v-src)
• Promoter Regions, Genetic
• Proto-Oncogene Proteins pp60(c-src)
• Recombinant Fusion Proteins