Article
Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527).
Molecular and cellular biology - 1 Dec 1991
Cobb B S, Payne D M, Reynolds A B, Parsons J T
Abstract excerpt
Repression of the tyrosine kinase activity of the cellular src protein (pp60c-src) depends on the phosphorylation of a tyrosine residue (Tyr-527) near the carboxy terminus. Tyr-527 is located 11 residues C terminal from the genetically defined end of the kinase domain (Leu-516) and is therefore i...
Topics
- Amino Acid Sequence
- Animals
- Cell Transformation, Neoplastic
- Chick Embryo
- Enzyme Activation
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Precipitin Tests
- Protein Conformation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins pp60(c-src)