Article
pp60c-src is required for the induction of a quiescent mesangial cell phenotype.
Kidney international - 1 Jan 1997
Marx M, Dorsch O
Abstract excerpt
The tyrosine kinase c-src associates with growth factor receptors, focal contacts and cytoskeletal proteins and is involved in signaling events. The aim of this study was to investigate the role of src in the regulation of mesangial cell (MC) proliferation and differentiation in three-dimensional (3D) culture in collagen gels. Using retroviral gene transfer we have overexpressed wild-type c-src, a kinase-negative...
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