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Article

Transforming activities of human CSF-1 receptors with different point mutations at codon 301 in their extracellular domains.

Oncogene - 1 Jan 1990

Roussel M F, Downing J R, Sherr C J

Abstract excerpt

Replacement of leucine 301 in the human colony stimulating factor 1 receptor (CSF-1R) by serine, threonine, glutamic acid, or proline induced ligand-independent transforming activity in mouse NIH3T3 cells, whereas substitution by phenylalanine, methionine, cysteine, or lysine did not. Serine, glutamic acid, and proline mutations were more potent than threonine in inducing cell transformation. The growth of cells...

Topics

Biological Transport
Cell Transformation, Neoplastic
Codon
Humans
Mutation
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
RNA, Messenger
Receptor, Macrophage Colony-Stimulating Factor
Receptors, Cell Surface

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PMID: 2157180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2157180-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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