Article
SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence.
Molecular and cellular biology - 1 Mar 1993
Pendergast A M, Gishizky M L, Havlik M H, Witte O N
Abstract excerpt
P210 BCR/ABL is a chimeric oncogene implicated in the pathogenesis of chronic myelogenous leukemia. BCR sequences have been shown to be required for activation of the tyrosine kinase and transforming functions of BCR/ABL. In this work, we show that two other structural requirements for full trans...
Topics
- Animals
- Cell Transformation, Neoplastic
- Fibroblasts
- Fusion Proteins, bcr-abl
- Genes, myc
- Genetic Complementation Test
- Growth Substances
- Leukemia, Myeloid
- Mice
- Mice, SCID
- Mutation
- Phenotype
- Phosphorylation
- Protein-Tyrosine Kinases
- Signal Transduction