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Article

SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence.

Molecular and cellular biology - 1 Mar 1993

Pendergast A M, Gishizky M L, Havlik M H, Witte O N

Abstract excerpt

P210 BCR/ABL is a chimeric oncogene implicated in the pathogenesis of chronic myelogenous leukemia. BCR sequences have been shown to be required for activation of the tyrosine kinase and transforming functions of BCR/ABL. In this work, we show that two other structural requirements for full transforming activity of P210 BCR/ABL include a functional tyrosine kinase and the presence of tyrosine 1294, a site of...

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Identifiers

PMID: 8441409
DOI: 10.1128/mcb.13.3.1728-1736.1993
PMCID: PMC359485

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence.PMID 8441409Read ↗

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