Article
Role of Gas1 down-regulation in mitogenic stimulation of quiescent NIH3T3 cells by v-Src.
Oncogene - 1 Oct 1998
Grossi M, La Rocca S A, Pierluigi G, Vannucchi S, Ruaro E M, Schneider C, Tatò F
Abstract excerpt
Quiescent mammalian fibroblasts can be induced to reenter the cell cycle by growth factors and oncoproteins. We studied the pathway(s) through which v-Src, the oncogenic tyrosine kinase encoded by the v-src oncogene of Rous sarcoma virus, forces serum-starved NIH3T3 cells to enter S-phase. To thi...
Topics
- 3T3 Cells
- Animals
- Cell Cycle Proteins
- Cell Division
- Cell Transformation, Neoplastic
- Chromones
- Down-Regulation
- Flavonoids
- GPI-Linked Proteins
- Gene Expression
- Membrane Proteins
- Mice
- Mitogen-Activated Protein Kinase Kinases
- Mitogens
- Morpholines
- Oncogene Protein pp60(v-src)
- Phenotype
- Phosphatidylinositol 3-Kinases