Article
Macrophage-colony-stimulating factor (CSF-1) induces proliferation, chemotaxis, and reversible monocytic differentiation in myeloid progenitor cells transfected with the human c-fms/CSF-1 receptor cDNA.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990
Pierce J H, Di Marco E, Cox G W, Lombardi D, Ruggiero M, Varesio L, Wang L M, Choudhury G G, Sakaguchi A Y, Di Fiore P P
Abstract excerpt
The c-fms protooncogene encodes the receptor for macrophage-colony-stimulating factor (CSF-1). Expression vectors containing either normal or oncogenic point-mutated human c-fms genes were transfected into interleukin 3 (IL-3)-dependent 32D cells in order to determine the effects of CSF-1 signaling in this murine clonal myeloid progenitor cell line. CSF-1 was shown to trigger proliferation in association with...
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