Article
The v-src oncogene may not be responsible for the increased radioresistance of hematopoietic progenitor cells expressing v-src.
Radiation research - 1 Mar 1992
Santucci M A, Anklesaria P, Anderson S M, Das I J, FitzGerald T J, Valinsky H, Kase K R, Sakakeeny M A, Greenberger J S
Abstract excerpt
Infection of the IL-3-dependent, myeloid progenitor cell line 32D cl 3 with murine retroviruses that contain either the wild-type or a temperature-sensitive mutant v-src can render these cells growth-factor independent. These cells also became resistant to gamma irradiation administered at the lo...
Topics
- Animals
- Cell Line
- Cell Survival
- Dose-Response Relationship, Radiation
- Gene Expression
- Hematopoietic Stem Cells
- Hot Temperature
- Interleukin-3
- Mice
- Mutation
- Oncogenes
- Radiation Tolerance
- Retroviridae Infections