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Article

Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain.

Molecular and cellular biology - 1 Jun 1990

O'Brien M C, Fukui Y, Hanafusa H

Abstract excerpt

To investigate the importance of a conserved region spanning residues 137 to 241 in the noncatalytic domain of p60c-src (SH2 region), we used oligonucleotide-directed mutagenesis to change residues that are highly conserved in this region. Chicken embryo fibroblasts infected with a p60c-src variant containing arginine instead of tryptophan at residue 148 (W148R) appeared more rounded than cells overexpressing a...

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Identifiers

PMID: 2111444
DOI: 10.1128/mcb.10.6.2855-2862.1990
PMCID: PMC360647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain.PMID 2111444Read ↗

Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.Semantic proximity Read ↗

Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527).Semantic proximity Read ↗

Mutational activation of pp60(c-src) leads to a tumorigenic phenotype in a preneoplastic Syrian hamster embryo cell line.Semantic proximity Read ↗

Highly conserved amino acids in the SH2 and catalytic domains of v-src are altered in naturally occurring, transformation-defective alleles.Semantic proximity Read ↗

Autophosphorylation is required for high kinase activity and efficient transformation ability of proteins encoded by host range alleles of v-src.Semantic proximity Read ↗

Acidic residues at the carboxyl terminus of p60c-src are required for regulation of tyrosine kinase activity and transformation.Semantic proximity Read ↗

Analysis of mutant forms of the c-src gene product containing a phenylalanine substitution for tyrosine 416.Semantic proximity Read ↗

The amino-terminal region of pp60c-src has a modulatory role and contains multiple sites of tyrosine phosphorylation.Semantic proximity Read ↗

Phenotypic changes induced by wild type and variant c-src genes carrying C-terminal sequence alterations.Semantic proximity Read ↗

Mutations in the SH3 domain of the src oncogene which decrease association of phosphatidylinositol 3'-kinase activity with pp60v-src and alter cellular morphology.Semantic proximity Read ↗

pp60v-src transformation of rat cells but not chicken cells strongly correlates with low-affinity phosphopeptide binding by the SH2 domain.Semantic proximity Read ↗

Tyrosine phosphorylation of three cellular proteins correlates with transformation of rat 1 cells by pp60src.Semantic proximity Read ↗

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