Article
Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain.
Molecular and cellular biology - 1 Jun 1990
O'Brien M C, Fukui Y, Hanafusa H
Abstract excerpt
To investigate the importance of a conserved region spanning residues 137 to 241 in the noncatalytic domain of p60c-src (SH2 region), we used oligonucleotide-directed mutagenesis to change residues that are highly conserved in this region. Chicken embryo fibroblasts infected with a p60c-src varia...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Evolution
- Cell Transformation, Neoplastic
- Cells, Cultured
- Chick Embryo
- Gene Expression Regulation
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Oncogene Protein pp60(v-src)
- Plasmids
- Protein-Tyrosine Kinases
- Proto-Oncogenes
- Retroviridae
- Sequence Homology, Nucleic Acid