Article
Association of low CYP3A activity with p53 mutation and CYP2D6 activity with Rb mutation in human bladder cancer.
Carcinogenesis - 1 May 1996
Romkes M, Chern H D, Lesnick T G, Becich M J, Persad R, Smith P, Branch R A
Abstract excerpt
p53 and Rb gene mutations are intermediate biomarkers useful for the prediction of neoplastic progression in bladder cancers. Previously, we have shown that low CYP3A activity, measured by dapsone N-hydroxylation, and high CYP2D6 activity, assessed by debrisoquine 4-hydroxylation, were significan...
Topics
- Aged
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System
- Genes, Retinoblastoma
- Genes, p53
- Glutathione Transferase
- Humans
- Mixed Function Oxygenases
- Mutation
- Oxidoreductases, N-Demethylating
- Urinary Bladder Neoplasms