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Article

The ability to 4-hydroxylate debrisoquine is related to recurrence of bladder cancer.

Pharmacogenetics - 1 Jun 1992

Fleming C M, Kaisary A, Wilkinson G R, Smith P, Branch R A

Abstract excerpt

Oxidative metabolism by cytochrome P450 enzymes is often involved in the activation of environmental procarcinogens. Debrisoquine, mephenytoin, and dapsone were used as in vivo probes for the activities of P4502D6, 2CMP, and 3A4, respectively, as well as dapsone for N-acetyltransferase, in order to assess the relationship between such activities and the relative risk of recurrence of bladder cancer. Urinary...

Topics

Aged
Biotransformation
Carcinogens, Environmental
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Debrisoquin
Female
Humans
Male
Middle Aged
Mixed Function Oxygenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Recurrence, Local

Phenotype

Risk Factors

Urinary Bladder Neoplasms

Source

Identifiers

PMID: 1306112
DOI: 10.1097/00008571-199206000-00004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1306112-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The ability to 4-hydroxylate debrisoquine is related to recurrence of bladder cancer.PMID 1306112Read ↗

Association of low CYP3A activity with p53 mutation and CYP2D6 activity with Rb mutation in human bladder cancer.Semantic proximity Read ↗

Correlation of polymorphic expression of CYP2D6 mRNA in bladder mucosa and tumor tissue to in vivo debrisoquine hydroxylase activity.Semantic proximity Read ↗

The procarcinogen hypothesis for bladder cancer: activities of individual drug metabolizing enzymes as risk factors.Semantic proximity Read ↗

Low activity of dapsone N-hydroxylation as a susceptibility risk factor in aggressive bladder cancer.Semantic proximity Read ↗

Mutant genes of cytochrome P-450IID6, glutathione S-transferase class Mu, and arylamine N-acetyltransferase in lung cancer patients.Semantic proximity Read ↗

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