Genetic predisposition to Balkan endemic nephropathy: ability to hydroxylate debrisoquine as a host risk factor.

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Article

Genetic predisposition to Balkan endemic nephropathy: ability to hydroxylate debrisoquine as a host risk factor.

IARC scientific publications - 1 Jan 1991

Nikolov I G, Chernozemsky I N, Idle J R

Abstract excerpt

The objective of this study was to examine the association between efficiency of oxidative metabolism and risk for developing Balkan endemic nephropathy (BEN) and/or transitional-cell carcinoma of the urinary tract, using a case-control design controlling for age, gender and socioeconomic factors. Over 900 urine samples were taken from 646 subjects, divided into the following groups: healthy subjects from areas...

Topics

Adult
Aged
Balkan Nephropathy
Bulgaria
Carcinoma, Transitional Cell
Case-Control Studies
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Debrisoquin
Disease Susceptibility
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Humans

Hydroxylation

Male

Middle Aged

Mixed Function Oxygenases

Oxidation-Reduction

Source

Open in PubMed

Identifiers

PMID: 1820343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1820343-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genetic predisposition to Balkan endemic nephropathy: ability to hydroxylate debrisoquine as a host risk factor.PMID 1820343Read ↗

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