Article
Correlation of polymorphic expression of CYP2D6 mRNA in bladder mucosa and tumor tissue to in vivo debrisoquine hydroxylase activity.
Carcinogenesis - 1 Sept 1994
Romkes-Sparks M, Mnuskin A, Chern H D, Persad R, Fleming C, Sibley G N, Smith P, Wilkinson G R, Branch R A
Abstract excerpt
Debrisoquine hydroxylase activity has been attributed to CYP2D6 and poor metabolizers of debrisoquine have a reduced relative risk of developing aggressive bladder cancer. Production of a proximate carcinogen could occur in liver or bladder mucosa. However, it is not known if CYP2D6 is expressed in human bladder mucosa. In vivo whole body debrisoquine hydroxylase activity was measured as the debrisoquine recovery...
Topics
- Base Sequence
- Case-Control Studies
- Cystoscopy
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Gene Expression
- Genotype
- Humans
- Hydroxylation
- Leukocytes