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Article

Debrisoquine hydroxylase gene polymorphism in neurofibromatosis type 1.

Anticancer research - 1 Jan 2000

Wundrack I, Sasiadek M, Blin N

Abstract excerpt

Cytochrome P450 CYP2D6 polymorphism is an autosomal recessive trait leading to impaired sparteine/ debrisoquine metabolism in 5-10% of the Caucasian population. Previous studies have associated affected individuals (poor metabolizers = PM) with susceptibility to bladder cancer and various forms of leukemia. In many other cancer forms, the data remain contradictory. A PCR assay allows the convenient screening of...

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PMID: 9494560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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