Article
Debrisoquine hydroxylase gene polymorphism in neurofibromatosis type 1.
Anticancer research - 1 Jan 2000
Wundrack I, Sasiadek M, Blin N
Abstract excerpt
Cytochrome P450 CYP2D6 polymorphism is an autosomal recessive trait leading to impaired sparteine/ debrisoquine metabolism in 5-10% of the Caucasian population. Previous studies have associated affected individuals (poor metabolizers = PM) with susceptibility to bladder cancer and various forms o...
Topics
- Adolescent
- Adult
- Alleles
- Cytochrome P-450 CYP2D6
- Exons
- Female
- Genes, Recessive
- Humans
- Introns
- Leukemia
- Male
- Meningeal Neoplasms
- Meningioma
- Middle Aged
- Neurofibromatosis 1
- Neurofibromatosis 2
- Parkinson Disease
- Point Mutation