Article
Debrisoquine hydroxylase gene polymorphism in meningioma.
Acta neuropathologica - 1 Jan 1994
Wundrack I, Meese E, Müllenbach R, Blin N
Abstract excerpt
Cytochrome P450 CYP2D6 polymorphism is an autosomal recessive trait associated with impaired debrisoquine metabolism in 5-10% of caucasian populations. This polymorphism has been associated with susceptibility to Parkinson's disease, bladder cancer, various forms of leukemia and possibly melanoma. In many other cancer forms, the data remained contradictory due to the technical limitations for identifying affected...
Topics
- Alleles
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Female
- Genotype
- Humans
- Male
- Meningeal Neoplasms
- Meningioma
- Mixed Function Oxygenases
- Mutation
- Polymerase Chain Reaction