Article
The procarcinogen hypothesis for bladder cancer: activities of individual drug metabolizing enzymes as risk factors.
Pharmacogenetics - 1 Jan 1995
Branch R A, Chern H D, Adedoyin A, Romkes-Sparks M, Lesnick T G, Persad R, Wilkinson G R, Fleming C M, Dickinson A J, Sibley G
Abstract excerpt
Bladder cancer provides the most definitive example for an association between environmental agents and cancer. However, in the absence of industrial occupational exposure, the primary carcinogen is rarely identified, and the mechanisms involved in cancer formation are poorly understood. The envi...
Topics
- Aryl Hydrocarbon Hydroxylases
- Carcinogens
- Case-Control Studies
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System
- Humans
- Inactivation, Metabolic
- Mixed Function Oxygenases
- Phenotype
- Prodrugs
- Reference Values
- Risk Factors