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Article

The procarcinogen hypothesis for bladder cancer: activities of individual drug metabolizing enzymes as risk factors.

Pharmacogenetics - 1 Jan 1995

Branch R A, Chern H D, Adedoyin A, Romkes-Sparks M, Lesnick T G, Persad R, Wilkinson G R, Fleming C M, Dickinson A J, Sibley G

Abstract excerpt

Bladder cancer provides the most definitive example for an association between environmental agents and cancer. However, in the absence of industrial occupational exposure, the primary carcinogen is rarely identified, and the mechanisms involved in cancer formation are poorly understood. The environmental procarcinogen hypothesis of tumour pathogenesis proposes that many carcinogens require metabolic activation...

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PMID: 7581498
DOI: 10.1097/00008571-199512001-00009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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