Low activity of dapsone N-hydroxylation as a susceptibility risk factor in aggressive bladder cancer.

doi:10.1097/00008571-199408000-00004

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Article

Low activity of dapsone N-hydroxylation as a susceptibility risk factor in aggressive bladder cancer.

Pharmacogenetics - 1 Aug 1994

Fleming C M, Persad R, Kaisary A, Smith P, Adedoyin A, Porter J, Wilkinson G R, Branch R A

Abstract excerpt

N-arylamines involved in the pathogenesis of bladder cancer, require metabolic activation via N-hydroxylation. The efficiency of in vivo N-hydroxylation of dapsone, a non-carcinogenic arylamine, may, therefore, provide a host susceptibility measure of risk of developing bladder cancer. To investi...

Topics

Case-Control Studies
Dapsone
Genetic Predisposition to Disease
Humans
Hydroxylation
Inactivation, Metabolic
Phenotype
Risk Factors
United Kingdom
Urinary Bladder Neoplasms

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