Article
Genetic polymorphism of CYP2D6 and lung cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 1998
Shaw G L, Falk R T, Frame J N, Weiffenbach B, Nesbitt J C, Pass H I, Caporaso N E, Moir D T, Tucker M A
Abstract excerpt
Previous reports of the association of extensive debrisoquine metabolism, controlled by the cytochrome P450 CYP2D6, with increased lung cancer risk have been conflicting. We examined the hypothesis that genetic polymorphism at the CYP2D6 locus identifies individuals at increased risk for lung can...
Topics
- Adenocarcinoma
- Adult
- Aged
- Alleles
- Carcinoma, Small Cell
- Carcinoma, Squamous Cell
- Case-Control Studies
- Cytochrome P-450 CYP2D6
- Female
- Genetic Markers
- Genotype
- Germ-Line Mutation
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Polymorphism, Genetic
- Risk