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Article

New opportunities in cancer risk evaluation using PCR-based DNA analysis for CYP2D6.

Environmental health perspectives - 1 Oct 1993

Idle J R, Daly A K

Abstract excerpt

Genetic polymorphisms of drug-metabolizing enzymes, principally CYP2D6 (debrisoquine 4-hydroxylase), have long been considered influential on host responsiveness to environmental carcinogens. In several independent studies, lung cancer cases are more frequently associated with the extensive metabolizer phenotype of CYP2D6. However, assignment of phenotype has traditionally involved administration of debrisoquine...

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Identifiers

PMID: 8143602
DOI: 10.1289/ehp.93101s3117
PMCID: PMC1521176

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Source receipt: pubmed, retrieved 7 Sept 2026.

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New opportunities in cancer risk evaluation using PCR-based DNA analysis for CYP2D6.PMID 8143602Read ↗

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