Article
New opportunities in cancer risk evaluation using PCR-based DNA analysis for CYP2D6.
Environmental health perspectives - 1 Oct 1993
Idle J R, Daly A K
Abstract excerpt
Genetic polymorphisms of drug-metabolizing enzymes, principally CYP2D6 (debrisoquine 4-hydroxylase), have long been considered influential on host responsiveness to environmental carcinogens. In several independent studies, lung cancer cases are more frequently associated with the extensive metab...
Topics
- DNA, Neoplasm
- Genotype
- Humans
- Neoplasms
- Phenotype
- Polymerase Chain Reaction
- Risk Factors