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Article

Binding of APC to the Human Homolog of the <b> <i>Drosophila</i> </b> Discs Large Tumor Suppressor Protein

17 May 1996

Abstract excerpt

The adenomatous polyposis coli gene (APC) is mutated in familial adenomatous polyposis and in sporadic colorectal tumors, and its product binds to the adherens junction protein beta-catenin. Overexpression of APC blocks cell cycle progression. The APC-beta-catenin complex was shown to bind to DLG, the human homolog of the Drosophila discs large tumor suppressor protein. This interaction required the...

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PMID: 8638125
DOI: 10.1126/science.272.5264.1020

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