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Article

Association of the <i>APC</i> Gene Product with β-Catenin

10 Dec 1993

Abstract excerpt

Mutations in the human APC gene are linked to familial adenomatous polyposis and to the progression of sporadic colorectal and gastric tumors. To gain insight into APC function, APC-associated proteins were identified by immunoprecipitation experiments. Antibodies to APC precipitated a 95-kilodalton protein that was purified and identified by sequencing as beta-catenin, a protein that binds to the cell adhesion...

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PMID: 8259518
DOI: 10.1126/science.8259518

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