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Article

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes.

Scientific reports - 19 Feb 2020

Parker Taybor W, Neufeld Kristi L

Abstract excerpt

Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor Adenomatous Polyposis Coli (APC). APC is an essential component of a cytoplasmic protein complex that targets β-catenin for destruction. Following Wnt ligand presentation, this complex is inhibited. However, a role for APC in this inhibition has not...

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Identifiers

PMID: 32076059
DOI: 10.1038/s41598-020-59899-z
PMCID: PMC7031393

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