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Article

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly.

Science (New York, N.Y.) - 17 May 1996

Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P

Abstract excerpt

The adenomatous polyposis coli gene (APC) is mutated in most colon cancers. The APC protein binds to the cellular adhesion molecule beta-catenin, which is a mammalian homolog of ARMADILLO, a component of the WINGLESS signaling pathway in Drosophila development. Here it is shown that when beta-catenin is present in excess, APC binds to another component of the WINGLESS pathway, glycogen synthase kinase 3beta...

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Source

Identifiers

PMID: 8638126
DOI: 10.1126/science.272.5264.1023

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly.PMID 8638126Read ↗

A new Drosophila APC homologue associated with adhesive zones of epithelial cells.Semantic proximity Read ↗

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes.Semantic proximity Read ↗

Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification.Semantic proximity Read ↗

Human APC sequesters beta-catenin even in the absence of GSK-3beta in a Drosophila model.Semantic proximity Read ↗

gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.Semantic proximity Read ↗

Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex.Semantic proximity Read ↗

Wnt signalling and the actin cytoskeleton.Semantic proximity Read ↗

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.Semantic proximity Read ↗

Proteomic characterization of GSK3β knockout shows altered cell adhesion and metabolic pathway utilisation in colorectal cancer cells.Semantic proximity Read ↗

Destruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and Armadillo.Semantic proximity Read ↗

Identification of a link between the tumour suppressor APC and the kinesin superfamily.Semantic proximity Read ↗

Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC.Semantic proximity Read ↗

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