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Article

Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein.

PloS one - 1 Jan 2011

Zhang Zhenyi, Li Hua, Chen Leyi, Lu Xingyu, Zhang Jian, Xu Ping, Lin Kui, Wu Geng

Abstract excerpt

The human Discs Large 1 (DLG1) protein uses two of its three PDZ domains to interact with the C-terminal peptide of the Adenomatous Polyposis Coli (APC) tumor suppressor protein. The DLG1/APC complex inhibits the cell cycle progression from the G0/G1 to the S phase, regulates epithelial cell migration and morphogenesis, and is required for polarization of the microtubule cytoskeleton. However, the molecular...

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Share to Adenomatous Polyposis Coli Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21858148
DOI: 10.1371/journal.pone.0023507
PMCID: PMC3157396

Genes

APC
DLG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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