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Article

What can humans learn from flies about adenomatous polyposis coli?

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Sept 2002

Barth Angela I M, Nelson W James

Abstract excerpt

Somatic or inherited mutations in the adenomatous polyposis coli (APC) gene are a frequent cause of colorectal cancer in humans. APC protein has an important tumor suppression function to reduce cellular levels of the signaling protein beta-catenin and, thereby, inhibit beta-catenin and T-cell-factor-mediated gene expression. In addition, APC protein binds to microtubules in vertebrate cells and localizes to...

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Identifiers

PMID: 12210511
DOI: 10.1002/bies.10152
PMCID: PMC3368605

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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