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Article

A Drosophila APC tumour suppressor homologue functions in cellular adhesion.

Nature cell biology - 1 Mar 2002

Hamada Fumihiko, Bienz Mariann

Abstract excerpt

Adenomatous polyposis coli (APC) is an important tumour suppressor in the intestinal epithelium. Its function in reducing nuclear beta-catenin and T-cell factor (TCF)-mediated transcription is conserved from Drosophila to mammals. But APC proteins are also associated with the plasma membrane. Here, we show that mutational inactivation of Drosophila E-APC causes delocalization of Armadillo (the Drosophila...

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Source

Identifiers

PMID: 11862214
DOI: 10.1038/ncb755

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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