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Article

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the <i>Drosophila</i> discs large tumor suppressor protein

14 Oct 1997

Abstract excerpt

In the majority of cervical cancers, DNAs of high-risk mucosotpropic human papillomaviruses (HPVs), such as type 16, are maintained so as to express two viral proteins, E6 and E7, suggesting an essential importance to carcinogenesis. The high-risk HPV E6 proteins are known to inactivate p53 tumor suppressor protein but appear to have an additional, molecularly unknown function(s). In this study, we demonstrate...

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PMID: 9326658
DOI: 10.1073/pnas.94.21.11612

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