Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia.

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Article

Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia.

Blood - 15 Mar 1996

Cayuela J M, Madani A, Sanhes L, Stern M H, Sigaux F

Abstract excerpt

No constant genetic alteration has yet been unravelled in T-cell acute lymphoblastic leukemia (T-ALL), and, to date, the most frequent alteration, the SIL-TAL1 deletion, is found in approximately 20% of cases. Recently, two genes have been identified, the multiple tumor-suppressor gene 1 (MTS1) a...

Topics

Adult
Alleles
Base Sequence
Carrier Proteins
Cell Cycle Proteins
Child
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
DNA Mutational Analysis
Exons
Female
Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Rearrangement

Genes, Tumor Suppressor

Humans

Leukemia-Lymphoma, Adult T-Cell

Male

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 8630377

Genes

TAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8630377-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia.PMID 8630377Read ↗

Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias.Semantic proximity Read ↗

Genomic alterations of the p19ARF encoding exons in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group studySemantic proximity Read ↗

Frequent clonal loss of heterozygosity (LOH) in the chromosomal region 1p32 occurs in childhood T cell acute lymphoblastic leukemia (T-ALL) carrying rearrangements of the TAL1 gene.Semantic proximity Read ↗

Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.Semantic proximity Read ↗

Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes.Semantic proximity Read ↗

Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study.Semantic proximity Read ↗

SCL/Tal-1 expression in T-acute lymphoblastic leukemia: an immunohistochemical and genotypic study.Semantic proximity Read ↗

Rearrangements of the tal-1 locus as clonal markers for T cell acute lymphoblastic leukemia.Semantic proximity Read ↗

HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosisSemantic proximity Read ↗

Lineage specific demethylation of tal-1 gene breakpoint region determines the frequency of tal-1 deletions in alpha beta lineage T-cells.Semantic proximity Read ↗

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