Article
Frequent clonal loss of heterozygosity (LOH) in the chromosomal region 1p32 occurs in childhood T cell acute lymphoblastic leukemia (T-ALL) carrying rearrangements of the TAL1 gene.
Leukemia - 1 Mar 1997
Iolascon A, Faienza M F, Coppola B, Moretti A, Basso G, Amaru R, Viganò G, Biondi A
Abstract excerpt
Deletions and chromosomal translocations involving the 1p32 region, are frequently observed in T cell acute lymphoblastic leukemia (T-ALL). One of the most common genetic changes is the breakage of the TAL1 gene, which was originally described to be involved in the T-ALL carrying the t(1;14)(p32;...
Topics
- Adolescent
- Alleles
- Basic Helix-Loop-Helix Transcription Factors
- Blotting, Southern
- Child
- Child, Preschool
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- DNA-Binding Proteins
- Female
- Gene Deletion