Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.

doi:10.1084/jem.172.5.1403

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Article

Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.

The Journal of experimental medicine - 1 Nov 1990

Chen Q, Yang C Y, Tsan J T, Xia Y, Ragab A H, Peiper S C, Carroll A, Baer R

Abstract excerpt

The tal-1 proto-oncogene encodes a helix-loop-helix DNA-binding protein that has been implicated in the formation of T cell acute lymphoblastic leukemia (T-ALL). Patients with T-ALL harbor structural rearrangements of tal-1 that result from either local DNA deletion or t(1;14)(p34;q11) chromosome...

Topics

Adult
Alleles
Amino Acid Sequence
Base Sequence
Basic Helix-Loop-Helix Transcription Factors
Chromosome Mapping
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 14
DNA, Neoplasm
DNA-Binding Proteins
Exons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Leukemia, T-Cell

Male

Molecular Sequence Data

Proto-Oncogene Mas

Proto-Oncogene Proteins

Proto-Oncogenes

Source

Open in PubMed Open full text

Identifiers

PMID: 2230650
DOI: 10.1084/jem.172.5.1403
PMCID: PMC2188666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2230650-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.PMID 2230650Read ↗

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