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Article

Rearrangements of the tal-1 locus as clonal markers for T cell acute lymphoblastic leukemia.

The Journal of clinical investigation - 1 Jun 1991

Jonsson O G, Kitchens R L, Baer R J, Buchanan G R, Smith R G

Abstract excerpt

Normal and aberrant immune receptor gene assembly each produce site-specific DNA rearrangements in leukemic lymphoblasts. In either case, these rearrangements provide useful clonal markers for the leukemias in question. In the t(1;14)(p34;q11) translocation associated with T cell acute lymphoblastic leukemia (T-ALL), the breakpoints on chromosome 1 interrupt the tal-1 gene. A site-specific deletion interrupts the...

Topics

Alleles
Base Sequence
Bone Marrow
Chromosome Deletion
Gene Rearrangement
Humans
Leukemia-Lymphoma, Adult T-Cell
Molecular Sequence Data
Nucleic Acid Hybridization
Polymerase Chain Reaction
Translocation, Genetic

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Identifiers

PMID: 2040693
DOI: 10.1172/JCI115232
PMCID: PMC296958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2040693-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Rearrangements of the tal-1 locus as clonal markers for T cell acute lymphoblastic leukemia.PMID 2040693Read ↗

Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.Semantic proximity Read ↗

Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes.Semantic proximity Read ↗

Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group studySemantic proximity Read ↗

Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study.Semantic proximity Read ↗

Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group studySemantic proximity Read ↗

The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia.Semantic proximity Read ↗

Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Comparative analysis of T-cell receptor gene rearrangements at diagnosis and relapse of T-cell acute lymphoblastic leukemia (T-ALL) shows high stability of clonal markers for monitoring of minimal residual disease and reveals the occurrence of second T-ALLSemantic proximity Read ↗

V(D)J-mediated Translocations in Lymphoid Neoplasms: A Functional Assessment of Genomic Instability by Cryptic SitesSemantic proximity Read ↗

Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Frequent clonal loss of heterozygosity (LOH) in the chromosomal region 1p32 occurs in childhood T cell acute lymphoblastic leukemia (T-ALL) carrying rearrangements of the TAL1 gene.Semantic proximity Read ↗

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