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Article

HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis

1 Aug 2002

Abstract excerpt

The most frequent oncogenic activation events characterized in childhood T acute lymphoblastic leukemia (T-ALL) result in the transcriptional activation of genes coding for transcription factors. The main genes are TAL1/SCL, a member of the basic region helix-loop-helix gene family, and HOX11L2, a member of the homeobox-containing protein family. To gain insight into the pathogenesis of this type of hematologic...

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PMID: 12130513
DOI: 10.1182/blood-2001-11-0093

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