Article
Genomic alterations of the p19ARF encoding exons in T-cell acute lymphoblastic leukemia.
Blood - 1 Feb 1998
Gardie B, Cayuela J M, Martini S, Sigaux F
Abstract excerpt
We have previously shown that the disruption/deletion of the MTS(MTS1-MTS2) locus due to illegitimate V(D)J recombinase activity is a genetic event characteristic of T-cell acute lymphoblastic leukemia (T-ALL). Inactivation of the p16INK4a tumor suppressor protein, encoded by MTS1, is thought to be the major functional consequence of these chromosomal rearrangements. The two other cell cycle inhibitors encoded by...
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