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Article

Genomic alterations of the p19ARF encoding exons in T-cell acute lymphoblastic leukemia.

Blood - 1 Feb 1998

Gardie B, Cayuela J M, Martini S, Sigaux F

Abstract excerpt

We have previously shown that the disruption/deletion of the MTS(MTS1-MTS2) locus due to illegitimate V(D)J recombinase activity is a genetic event characteristic of T-cell acute lymphoblastic leukemia (T-ALL). Inactivation of the p16INK4a tumor suppressor protein, encoded by MTS1, is thought to be the major functional consequence of these chromosomal rearrangements. The two other cell cycle inhibitors encoded by...

Topics

Adolescent
Adult
Alleles
Blotting, Southern
Child
Female
Gene Deletion
Humans
Leukemia-Lymphoma, Adult T-Cell
Male
Polymerase Chain Reaction
Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

RNA-Directed DNA Polymerase

Recombination, Genetic

Thymus Gland

Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 9446664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9446664-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genomic alterations of the p19ARF encoding exons in T-cell acute lymphoblastic leukemia.PMID 9446664Read ↗

Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias.Semantic proximity Read ↗

Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

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