Article
Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes.
The Journal of experimental medicine - 1 Apr 1993
Breit T M, Mol E J, Wolvers-Tettero I L, Ludwig W D, van Wering E R, van Dongen J J
Abstract excerpt
Site-specific deletions in the tal-1 gene are reported to occur in 12-26% of T cell acute lymphoblastic leukemias (T-ALL). So far two main types of tal-1 deletions have been described. Upon analysis of 134 T-ALL we have found two new types of tal-1 deletions. These four types of deletions juxtapo...
Topics
- Base Sequence
- Basic Helix-Loop-Helix Transcription Factors
- Blotting, Southern
- CD3 Complex
- DNA, Neoplasm
- DNA-Binding Proteins
- Gene Deletion
- Humans
- Intracellular Signaling Peptides and Proteins
- Molecular Sequence Data
- Oncogene Proteins, Fusion
- Phenotype
- Polymerase Chain Reaction