Article
Lineage specific demethylation of tal-1 gene breakpoint region determines the frequency of tal-1 deletions in alpha beta lineage T-cells.
Oncogene - 1 Jul 1994
Breit T M, Wolvers-Tettero I L, van Dongen J J
Abstract excerpt
tal-1 deletions are caused by a site specific recombination, which exclusively occurs in 12-26% of T-cell acute lymphoblastic leukemias (T-ALL). In a previous study on a large series of T-ALL we demonstrated an apparent preferential occurrence of tal-1 deletions in CD3- and CD3+ alpha beta lineag...
Topics
- Base Sequence
- Basic Helix-Loop-Helix Transcription Factors
- CD3 Complex
- Cells, Cultured
- Child
- DNA Primers
- DNA, Neoplasm
- DNA-Binding Proteins
- Gene Deletion
- Humans
- Intracellular Signaling Peptides and Proteins
- Leukemia, B-Cell
- Leukemia, Myeloid, Acute
- Leukemia, T-Cell
- Methylation
- Molecular Sequence Data
- Oncogene Proteins, Fusion
- Phenotype