Article
Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia? A pediatric oncology group study.
Blood - 15 Jul 1995
Bash R O, Hall S, Timmons C F, Crist W M, Amylon M, Smith R G, Baer R
Abstract excerpt
Almost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL) have tumor-specific rearrangements of the TAL1 gene. Although TAL1 expression has not been observed in normal lymphocytes, TAL1 gene products are readily detected in leukemic cells that harbor a rearranged TAL1 allele. Hence,...
Topics
- Alleles
- Base Sequence
- Basic Helix-Loop-Helix Transcription Factors
- Bone Marrow
- Burkitt Lymphoma
- Child
- DNA, Neoplasm
- DNA-Binding Proteins
- Gene Expression Regulation, Leukemic
- Gene Rearrangement
- Humans
- Leukemia-Lymphoma, Adult T-Cell
- Molecular Sequence Data
- Neoplasm Proteins