Article
Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias.
Blood - 15 Dec 1994
Hebert J, Cayuela J M, Berkeley J, Sigaux F
Abstract excerpt
Using a Southern blot approach, deletions of MTS1 (multiple tumor-suppressor gene 1) and MTS2 (multiple tumor-suppressor gene 2) candidate tumor-suppressor genes have been studied in primary neoplastic cells from 55 acute lymphoblastic leukemia (ALL) patients. Homozygous MTS1 deletions were found...
Topics
- Adolescent
- Adult
- Base Sequence
- Blotting, Southern
- Burkitt Lymphoma
- Carrier Proteins
- Child
- Child, Preschool
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p16
- DNA, Neoplasm
- Genes, Tumor Suppressor
- Genotype
- Humans
- Infant
- Leukemia-Lymphoma, Adult T-Cell
- Leukocytes, Mononuclear
- Middle Aged