Article
Limited genetic changes in the Sabin 1 strain of poliovirus occurring in the central nervous system of monkeys.
The Journal of general virology - 1 Feb 1996
Lu Z, Rezapkin G V, Douthitt M P, Ran Y, Asher D M, Levenbook I S, Chumakov K M
Abstract excerpt
Replication of attenuated poliovirus strains results in their partial deattenuation. Recently we identified mutations accumulating in the Sabin 1 poliovirus in cell cultures. Here we report genetic changes occurring in this virus during replication in the central nervous system (CNS) of monkeys. Viruses isolated from different parts of the CNS of rhesus monkeys (inoculated into the spinal cord) were screened for...
Topics
- Animals
- Base Sequence
- Genome, Viral
- Macaca mulatta
- Molecular Sequence Data
- Mutation
- Poliovirus
- Poliovirus Vaccine, Oral
- Spinal Cord