Changes in population dynamics during long-term evolution of sabin type 1 poliovirus in an immunodeficient patient.

doi:10.1128/JVI.00468-08

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Article

Changes in population dynamics during long-term evolution of sabin type 1 poliovirus in an immunodeficient patient.

Journal of virology - 1 Sept 2008

Odoom John K, Yunus Zaira, Dunn Glynis, Minor Philip D, Martín Javier

Abstract excerpt

The evolution of the Sabin strain of type 1 poliovirus in a hypogammaglobulinemia patient for a period of 649 days is described. Twelve poliovirus isolates from sequential stool samples encompassing days 21 to 649 after vaccination with Sabin 1 were characterized in terms of their antigenic properties, virulence in transgenic mice, sensitivity for growth at high temperatures, and differences in nucleotide...

Topics

Agammaglobulinemia
Animals
Antigens, Viral
Base Sequence
Cell Line
Child, Preschool
Evolution, Molecular
Feces
Humans
Immunization
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Molecular Sequence Data

Mutation

Phylogeny

Poliovirus

Poliovirus Vaccine, Oral

Source

Open in PubMed Open full text

Identifiers

PMID: 18596089
DOI: 10.1128/JVI.00468-08
PMCID: PMC2546908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18596089-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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