Article
Evolution of the Sabin type 1 poliovirus in humans: characterization of strains isolated from patients with vaccine-associated paralytic poliomyelitis.
Journal of virology - 1 Oct 1997
Georgescu M M, Balanant J, Macadam A, Otelea D, Combiescu M, Combiescu A A, Crainic R, Delpeyroux F
Abstract excerpt
Attenuated strains of the Sabin oral poliovirus vaccine replicate in the human gut and in rare cases cause vaccine-associated paralytic poliomyelitis (VAPP). Reversion of vaccine strains toward a pathogenic phenotype is probably one of the main causes of VAPP, a disease most frequently associated...
Topics
- Animals
- Base Sequence
- Genotype
- Humans
- Mice
- Phenotype
- Poliomyelitis
- Poliovirus
- Poliovirus Vaccine, Oral
- RNA, Viral
- Serotyping
- Tumor Cells, Cultured
- Virulence
- Virus Replication