Mutations in Sabin 2 strain of poliovirus and stability of attenuation phenotype.

doi:10.1006/viro.1999.9718

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Article

Mutations in Sabin 2 strain of poliovirus and stability of attenuation phenotype.

Virology - 25 May 1999

Rezapkin G V, Fan L, Asher D M, Fibi M R, Dragunsky E M, Chumakov K M

Abstract excerpt

In this study, we attempted to identify the molecular determinants in the genome of the attenuated Sabin 2 vaccine strain of poliovirus that may change during vaccine production and result in an increase in monkey neurovirulence. An extensive search for suitable vaccine lots identified six batche...

Topics

5' Untranslated Regions
Animals
Capsid
Capsid Proteins
Humans
Macaca mulatta
Membrane Proteins
Mice
Mice, Transgenic
Mutagenesis
Phenotype
Poliovirus
Poliovirus Vaccine, Oral
Receptors, Virus
Vaccines, Attenuated
Virulence

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