Article
Mutations in Sabin 2 strain of poliovirus and stability of attenuation phenotype.
Virology - 25 May 1999
Rezapkin G V, Fan L, Asher D M, Fibi M R, Dragunsky E M, Chumakov K M
Abstract excerpt
In this study, we attempted to identify the molecular determinants in the genome of the attenuated Sabin 2 vaccine strain of poliovirus that may change during vaccine production and result in an increase in monkey neurovirulence. An extensive search for suitable vaccine lots identified six batches that had failed the monkey neurovirulence test (MNVT). On repeated tests, these batches were found to have acceptable...
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