Article
Increased neurovirulence associated with a single nucleotide change in a noncoding region of the Sabin type 3 poliovaccine genome.
Nature - 1 Jan 2000
Evans D M, Dunn G, Minor P D, Schild G C, Cann A J, Stanway G, Almond J W, Currey K, Maizel J V
Abstract excerpt
Most of the small number of cases of poliomyelitis which occur in countries where Sabin's attenuated poliovirus vaccines are used are temporally associated with administration of vaccine and involve polioviruses of types 2 and 3 (ref. 1). Recent studies have provided convincing evidence that the Sabin type 2 and 3 viruses themselves may revert to a neurovirulent phenotype on passage in man. We report here that a...
Topics
- Base Sequence
- DNA, Viral
- Feces
- Genes, Viral
- Humans
- Infant
- Mutation
- Nucleic Acid Conformation
- Poliomyelitis
- Poliovirus
- Poliovirus Vaccine, Oral