Succession of mutations in the Sabin strain of type 3 poliovirus replicating in the central nervous system of monkeys.

doi:10.1006/viro.1996.0316

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Article

Succession of mutations in the Sabin strain of type 3 poliovirus replicating in the central nervous system of monkeys.

Virology - 15 Jun 1996

Lu Z, Asher D M, Levenbook I S, Chumakov K M

Abstract excerpt

Sabin strains of oral poliovirus vaccine (OPV) undergo limited genetic changes during replication in cell cultures, the gastrointestinal tract of vaccinees, and the central nervous system of monkeys. Some of these changes are associated with loss of attenuation markers. Here we report the dynamic...

Topics

Animals
Central Nervous System
Humans
Macaca mulatta
Mutation
Poliomyelitis
Poliovirus
Poliovirus Vaccine, Oral
Temperature
Time Factors
Tumor Cells, Cultured
Virus Replication

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