Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Succession of mutations in the Sabin strain of type 3 poliovirus replicating in the central nervous system of monkeys.

Virology - 15 Jun 1996

Lu Z, Asher D M, Levenbook I S, Chumakov K M

Abstract excerpt

Sabin strains of oral poliovirus vaccine (OPV) undergo limited genetic changes during replication in cell cultures, the gastrointestinal tract of vaccinees, and the central nervous system of monkeys. Some of these changes are associated with loss of attenuation markers. Here we report the dynamics of mutant accumulation in the Sabin strain of poliovirus type 3 inoculated intraspinally into monkeys. Thr --> lle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Central Nervous System
Share to Macaca mulatta
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Poliovirus

Share to Temperature

Share to Time Factors

Share to Tumor Cells, Cultured

Share to Virus Replication

Source

Identifiers

PMID: 8661379
DOI: 10.1006/viro.1996.0316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Succession of mutations in the Sabin strain of type 3 poliovirus replicating in the central nervous system of monkeys.PMID 8661379Read ↗

Limited genetic changes in the Sabin 1 strain of poliovirus occurring in the central nervous system of monkeys.Semantic proximity Read ↗

Increased neurovirulence associated with a single nucleotide change in a noncoding region of the Sabin type 3 poliovaccine genome.Semantic proximity Read ↗

Microevolution of type 3 Sabin strain of poliovirus in cell cultures and its implications for oral poliovirus vaccine quality control.Semantic proximity Read ↗

Identification and characterization of a new base substitution in the vaccine strain of Sabin 3 poliovirus.Semantic proximity Read ↗

Mutations in Sabin 2 strain of poliovirus and stability of attenuation phenotype.Semantic proximity Read ↗

Microevolution of Sabin 1 strain in vitro and genetic stability of oral poliovirus vaccine.Semantic proximity Read ↗

Evolution of the Sabin type 1 poliovirus in humans: characterization of strains isolated from patients with vaccine-associated paralytic poliomyelitis.Semantic proximity Read ↗

Significance of a newly identified attenuating mutation in Sabin 3 oral poliovirus vaccine.Semantic proximity Read ↗

Genomic modifications in naturally occurring neurovirulent revertants of Sabin 1 polioviruses.Semantic proximity Read ↗

Evolution of the Sabin Strain of Type 3 Poliovirus in an Immunodeficient Patient during the Entire 637-Day Period of Virus ExcretionSemantic proximity Read ↗

A mutation present in the amino terminus of Sabin 3 poliovirus VP1 protein is attenuating.Semantic proximity Read ↗

Changes in population dynamics during long-term evolution of sabin type 1 poliovirus in an immunodeficient patient.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.