Article
Microevolution of type 3 Sabin strain of poliovirus in cell cultures and its implications for oral poliovirus vaccine quality control.
Virology - 20 Aug 1995
Rezapkin G V, Norwood L P, Taffs R E, Dragunsky E M, Levenbook I S, Chumakov K M
Abstract excerpt
Screening for sequence heterogeneities in Sabin Type 3 strains of attenuated poliovirus demonstrated mutations that consistently accumulate to significant levels following 10 passages in cultures of primary African green monkey kidney (AGMK) cells or continuous cultures of Vero cells. Fourteen ne...
Topics
- Animals
- Base Sequence
- Biological Evolution
- Cell Line
- Chlorocebus aethiops
- Genome, Viral
- Molecular Sequence Data
- Mutation
- Poliovirus
- Poliovirus Vaccine, Oral
- Quality Control
- Serial Passage
- Species Specificity
- Vero Cells