Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping of mutations associated with neurovirulence in monkeys infected with Sabin 1 poliovirus revertants selected at high temperature.

Journal of virology - 1 Oct 1990

Christodoulou C, Colbere-Garapin F, Macadam A, Taffs L F, Marsden S, Minor P, Horaud F

Abstract excerpt

Poliovirus type 1 neurovirulence is difficult to analyze because of the 56 mutations which differentiate the neurovirulent Mahoney strain from the attenuated Sabin strain. We have isolated four neurovirulent mutants which differ from the temperature-sensitive parental Sabin 1 strain by only a few mutations, using selection for temperature resistance: mutant S(1)37C1 was isolated at 37.5 degrees C, S(1)38C5 was...

Topics

Animals
Capsid
Cell Line
Codon
Electrophoresis, Gel, Two-Dimensional
Electrophoresis, Polyacrylamide Gel
Humans
Macaca fascicularis
Mutation
Phenotype
Poliovirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Poliovirus Vaccine, Oral

RNA, Viral

Viral Proteins

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 2168976
DOI: 10.1128/JVI.64.10.4922-4929.1990
PMCID: PMC247983

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2168976-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping of mutations associated with neurovirulence in monkeys infected with Sabin 1 poliovirus revertants selected at high temperature.PMID 2168976Read ↗

Mapping of mutations contributing to the temperature sensitivity of the Sabin 1 vaccine strain of poliovirus.Semantic proximity Read ↗

Limited genetic changes in the Sabin 1 strain of poliovirus occurring in the central nervous system of monkeys.Semantic proximity Read ↗

Role of mutations G-480 and C-6203 in the attenuation phenotype of Sabin type 1 poliovirus.Semantic proximity Read ↗

Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeysSemantic proximity Read ↗

Evolution of the Sabin type 1 poliovirus in humans: characterization of strains isolated from patients with vaccine-associated paralytic poliomyelitis.Semantic proximity Read ↗

Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccineSemantic proximity Read ↗

Microevolution of Sabin 1 strain in vitro and genetic stability of oral poliovirus vaccine.Semantic proximity Read ↗

Correlation of mutations and recombination with growth kinetics of poliovirus vaccine strains.Semantic proximity Read ↗

A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in miceSemantic proximity Read ↗

Genomic modifications in naturally occurring neurovirulent revertants of Sabin 1 polioviruses.Semantic proximity Read ↗

Elongation activity of poliovirus RNA polymerase derived from Sabin type 1 sequence is not temperature sensitive.Semantic proximity Read ↗

Identification of a consistent pattern of mutations in neurovirulent variants derived from the sabin vaccine strain of poliovirus type 2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.