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Article

Identification of a consistent pattern of mutations in neurovirulent variants derived from the sabin vaccine strain of poliovirus type 2.

Journal of virology - 1 May 1991

Equestre M, Genovese D, Cavalieri F, Fiore L, Santoro R, Perez Bercoff R

Abstract excerpt

Complete nucleotide sequencing of the RNAs of two unrelated neurovirulent isolates of Sabin-related poliovirus type 2 revealed that two nucleotides and one amino acid (amino acid 143 in the major capsid protein VP1) consistently departed from the sequences of the nonneurovirulent poliovirus type 2 712 and Sabin vaccine strains. This pattern of mutation appeared to be a feature common to all neurovirulent variants...

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Identifiers

PMID: 1850043
DOI: 10.1128/JVI.65.5.2707-2710.1991
PMCID: PMC240633

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