Article
Identification of a consistent pattern of mutations in neurovirulent variants derived from the sabin vaccine strain of poliovirus type 2.
Journal of virology - 1 May 1991
Equestre M, Genovese D, Cavalieri F, Fiore L, Santoro R, Perez Bercoff R
Abstract excerpt
Complete nucleotide sequencing of the RNAs of two unrelated neurovirulent isolates of Sabin-related poliovirus type 2 revealed that two nucleotides and one amino acid (amino acid 143 in the major capsid protein VP1) consistently departed from the sequences of the nonneurovirulent poliovirus type...
Topics
- Amino Acid Sequence
- Base Sequence
- Capsid
- Capsid Proteins
- DNA Mutational Analysis
- DNA, Viral
- Molecular Sequence Data
- Mutation
- Poliovirus
- Poliovirus Vaccine, Oral
- Sequence Homology, Nucleic Acid
- Spinal Diseases
- Virulence