Article
In vivo selection of a hepatitis B virus mutant with abnormal viral protein expression.
The Journal of general virology - 1 May 1996
Kremsdorf D, Garreau F, Capel F, Petit M A, Brechot C
Abstract excerpt
We have investigated the molecular basis for the in vivo selective advantage of a hepatitis B virus (HBV) mutant. We have determined the complete nucleotide sequences of the major HBV forms identified at the beginning (B1-83) and end (B1-89) of a 6 year follow-up of a chronically infected patient. The B1-89 sequence showed marked nucleotide rearrangements (a nucleotide divergence of 11.3 % compared with the adw2...
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